| 1. Jornada | 13.08.2021 | Hamrun Spartans | - | Valletta FC | 1:2 | ||||
| 2. Jornada | 21.08.2021 | Birkirkara FC | - | Hamrun Spartans | 2:1 |  |
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| 3. Jornada | 11.09.2021 | Mosta FC | - | Hamrun Spartans | 1:2 | |
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| 4. Jornada | 19.09.2021 | Hamrun Spartans | - | Balzan FC | 0:1 | ||||
| 5. Jornada | 25.09.2021 | Floriana FC | - | Hamrun Spartans | 1:2 | ||||
| 6. Jornada | 16.10.2021 | Hamrun Spartans | - | Gżira United | 0:1 | ||||
| 15. Jornada | 22.01.2022 | Balzan FC | - | Hamrun Spartans | 2:2 | ||||
| 13. Jornada | 26.01.2022 | Hamrun Spartans | - | Birkirkara FC | 0:0 | ||||
| 16. Jornada | 30.01.2022 | Hamrun Spartans | - | Floriana FC | 2:2 | |
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| 17. Jornada | 05.02.2022 | Gżira United | - | Hamrun Spartans | 4:1 | ||||
| 18. Jornada | 13.02.2022 | Hamrun Spartans | - | Gudja United | 0:1 | ||||
| 19. Jornada | 19.02.2022 | Sirens FC | - | Hamrun Spartans | 1:1 | ||||
| 20. Jornada | 26.02.2022 | Hamrun Spartans | - | Hibernians FC | 0:0 | ||||
| 21. Jornada | 06.03.2022 | St. Luċija FC | - | Hamrun Spartans | 0:1 | ||||
| 22. Jornada | 11.03.2022 | Hamrun Spartans | - | Sliema Wanderers | 3:1 |
Cabo Verde