| 2. Jornada | 01.08.2021 | FC DAC 1904 | - | Tatran Liptovský Mikuláš | 3:1 | ||||
| 3. Jornada | 08.08.2021 | ŠKF Sereď | - | FC DAC 1904 | 1:0 | ||||
| 4. Jornada | 14.08.2021 | FK Senica | - | FC DAC 1904 | 1:1 |  |
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| 11. Jornada | 16.10.2021 | MŠK Žilina | - | FC DAC 1904 | 0:2 |  |
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| 12. Jornada | 24.10.2021 | FC DAC 1904 | - | MFK Zemplín Michalovce | 1:0 | ||||
| 13. Jornada | 30.10.2021 | Tatran Liptovský Mikuláš | - | FC DAC 1904 | 1:0 | ||||
| 14. Jornada | 06.11.2021 | FC DAC 1904 | - | ŠKF Sereď | 1:3 | ||||
| 15. Jornada | 20.11.2021 | FC DAC 1904 | - | FK Senica | 1:0 | ||||
| 16. Jornada | 27.11.2021 | AS Trenčín | - | FC DAC 1904 | 0:1 | ||||
| 17. Jornada | 04.12.2021 | FC DAC 1904 | - | FK Pohronie | 2:0 | ||||
| 18. Jornada | 12.12.2021 | Slovan Bratislava | - | FC DAC 1904 | 0:0 | ||||
| 19. Jornada | 17.12.2021 | FC DAC 1904 | - | MFK Ružomberok | 0:0 | ||||
| 20. Jornada | 13.02.2022 | Spartak Trnava | - | FC DAC 1904 | 1:1 | |
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| 22. Jornada | 26.02.2022 | FC DAC 1904 | - | MŠK Žilina | 3:1 |
Eslovaquia