| 3. Jornada | 26.04.2021 | Puerto Montt | - | San Luis | 2:1 | ||||
| 5. Jornada | 09.05.2021 | Deportes Iquique | - | San Luis | 0:0 | ||||
| 11. Jornada | 15.07.2021 | Santiago Morning | - | San Luis | 0:0 | ||||
| 13. Jornada | 01.08.2021 | Coquimbo Unido | - | San Luis | 0:1 | ||||
| 14. Jornada | 10.08.2021 | San Luis | - | CD Magallanes | 1:1 |  |
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| 15. Jornada | 17.08.2021 | Barnechea | - | San Luis | 0:0 | ||||
| 16. Jornada | 23.08.2021 | San Luis | - | Deportes Temuco | 1:1 |  |
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| 17. Jornada | 28.08.2021 | Rangers | - | San Luis | 0:1 | ||||
| 18. Jornada | 01.09.2021 | San Luis | - | Puerto Montt | 0:1 | ||||
| 19. Jornada | 07.09.2021 | Unión San Felipe | - | San Luis | 1:1 |  |
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| 21. Jornada | 22.09.2021 | Fernández Vial | - | San Luis | 2:2 | ||||
| 22. Jornada | 26.09.2021 | Deportes Copiapó | - | San Luis | 4:1 | ||||
| 23. Jornada | 02.10.2021 | San Luis | - | Cobreloa | 1:0 | ||||
| 30. Jornada | 12.11.2021 | San Luis | - | Barnechea | 2:1 |
Chile