| 1. Jornada | 01.08.2021 | Alianza | - | Municipal Limeño | 4:1 |  |
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| 2. Jornada | 08.08.2021 | Platense Zacatecoluca | - | Alianza | 2:2 | ||||
| 3. Jornada | 11.08.2021 | AD Chalatenango | - | Alianza | 2:1 | |
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| 4. Jornada | 15.08.2021 | Alianza | - | Luis Ángel Firpo | 2:2 | ||||
| 6. Jornada | 26.08.2021 | Alianza | - | FAS | 1:0 | ||||
| 9. Jornada | 16.09.2021 | Santa Tecla FC | - | Alianza | 0:4 | |
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| 10. Jornada | 19.09.2021 | Alianza | - | CD Águila | 2:1 | ||||
| 11. Jornada | 25.09.2021 | Jocoro FC | - | Alianza | 3:3 | |
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| 12. Jornada | 02.10.2021 | Municipal Limeño | - | Alianza | 0:3 | ||||
| 13. Jornada | 17.10.2021 | Alianza | - | Platense Zacatecoluca | 4:0 | |
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| 14. Jornada | 21.10.2021 | Alianza | - | AD Chalatenango | 1:0 | ||||
| 15. Jornada | 24.10.2021 | Luis Ángel Firpo | - | Alianza | 2:1 | ||||
| 16. Jornada | 30.10.2021 | Once Municipal | - | Alianza | 2:3 | |
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| 17. Jornada | 02.11.2021 | FAS | - | Alianza | 0:1 | |
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| 18. Jornada | 06.11.2021 | Alianza | - | Isidro Metapán | 1:0 | ||||
| 19. Jornada | 13.11.2021 | Atlético Marte | - | Alianza | 2:1 | ||||
| 20. Jornada | 18.11.2021 | Alianza | - | Santa Tecla FC | 5:0 | |
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| 21. Jornada | 21.11.2021 | CD Águila | - | Alianza | 0:1 | |
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| 22. Jornada | 27.11.2021 | Alianza | - | Jocoro FC | 2:0 | |
Colombia