| 1. Jornada | 19.01.2025 | UD Universitario | - | San Francisco FC | 1:1 | ||||
| 5. Jornada | 18.02.2025 | Veraguas United | - | San Francisco FC | 0:0 |  |
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| 6. Jornada | 22.02.2025 | San Francisco FC | - | Tauro FC | 1:1 | ||||
| 7. Jornada | 26.02.2025 | San Francisco FC | - | Plaza Amador | 0:1 | ||||
| 8. Jornada | 11.03.2025 | Potros del Este | - | San Francisco FC | 0:1 | ||||
| 9. Jornada | 15.03.2025 | Sporting San Miguelito | - | San Francisco FC | 0:1 | ||||
| 10. Jornada | 23.03.2025 | Árabe Unido | - | San Francisco FC | 1:3 | ||||
| 11. Jornada | 29.03.2025 | San Francisco FC | - | Alianza | 1:2 | ||||
| 12. Jornada | 05.04.2025 | San Francisco FC | - | Veraguas United | 4:0 | |
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| 13. Jornada | 12.04.2025 | San Francisco FC | - | Herrera FC | 1:1 | ||||
| 14. Jornada | 26.04.2025 | San Francisco FC | - | Independiente de La Chorrera | 1:1 | ||||
| 15. Jornada | 03.05.2025 | UMECIT | - | San Francisco FC | 2:0 | |
Panamá