| 1. Jornada | 21.07.2012 | Club Tijuana | - | Puebla FC | 2:0 | ||||
| 2. Jornada | 29.07.2012 | Puebla FC | - | Deportivo Toluca | 1:3 |  |
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| 3. Jornada | 04.08.2012 | Santos Laguna | - | Puebla FC | 2:2 | ||||
| 6. Jornada | 26.08.2012 | Puebla FC | - | Club San Luis | 1:0 | ||||
| 7. Jornada | 03.09.2012 | Deportivo Guadalajara | - | Puebla FC | 1:1 | ||||
| 9. Jornada | 22.09.2012 | Puebla FC | - | Club León | 1:1 | ||||
| 10. Jornada | 30.09.2012 | Pumas UNAM | - | Puebla FC | 2:1 | ||||
| 11. Jornada | 04.10.2012 | Puebla FC | - | CF Pachuca | 2:0 | ||||
| 12. Jornada | 07.10.2012 | UANL Tigres | - | Puebla FC | 1:2 | |
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| 14. Jornada | 20.10.2012 | Jaguares Chiapas | - | Puebla FC | 2:0 | ||||
| 13. Jornada | 26.10.2012 | Puebla FC | - | CF América | 0:1 | ||||
| 15. Jornada | 28.10.2012 | Puebla FC | - | Atlante | 1:2 | ||||
| 16. Jornada | 04.11.2012 | Atlas Guadalajara | - | Puebla FC | 2:2 | ||||
| 17. Jornada | 11.11.2012 | Puebla FC | - | Gallos Blancos (old) | 0:1 |
Colombia