| 1. Jornada | 24.07.2021 | Cruz Azul [Sub 16] | - | Pumas UNAM [Sub 16] | 0:0 | ||||
| 2. Jornada | 31.07.2021 | CF Pachuca [Sub 16] | - | Cruz Azul [Sub 16] | 1:2 | ||||
| 3. Jornada | 07.08.2021 | Cruz Azul [Sub 16] | - | Club Tijuana [Sub 16] | 3:0 | ||||
| 4. Jornada | 14.08.2021 | Gallos Blancos [Sub 16] | - | Cruz Azul [Sub 16] | 3:0 | ||||
| 5. Jornada | 21.08.2021 | Cruz Azul [Sub 16] | - | Deportivo Toluca [Sub 16] | 1:2 | ||||
| 7. Jornada | 04.09.2021 | Cruz Azul [Sub 16] | - | FC Juárez [Sub 16] | 1:0 | ||||
| 14. Jornada | 23.10.2021 | Cruz Azul [Sub 16] | - | CF América [Sub 16] | 2:2 | ||||
| 16. Jornada | 06.11.2021 | Cruz Azul [Sub 16] | - | Puebla FC [Sub 16] | 0:2 |
México