| 10. Jornada | 03.09.2022 | Tigres FC | - | Real Santander | 2:2 | ||||
| 11. Jornada | 07.09.2022 | Real Santander | - | Valledupar FC | 1:0 | ||||
| 12. Jornada | 14.09.2022 | Barranquilla FC | - | Real Santander | 2:1 | ||||
| 13. Jornada | 19.09.2022 | Real Santander | - | Boyacá Chicó | 0:0 | ||||
| 14. Jornada | 23.09.2022 | Cúcuta Deportivo | - | Real Santander | 0:0 | ||||
| 15. Jornada | 03.10.2022 | Real Santander | - | Atlético Huila | 2:1 | ||||
| 16. Jornada | 08.10.2022 | Boca Juniors de Cali | - | Real Santander | 2:3 |
Colombia