| 3. Jornada | 03.04.2021 | Bolívar | - | Blooming | 2:0 | ||||
| 6. Jornada | 04.05.2021 | Blooming | - | Club San José | 4:0 |  |
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| 7. Jornada | 07.05.2021 | Real Santa Cruz | - | Blooming | 1:0 | ||||
| 16. Jornada | 18.08.2021 | CD Guabirá | - | Blooming | 4:2 |  |
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| 17. Jornada | 22.08.2021 | Independiente Petrolero | - | Blooming | 3:0 | ||||
| 18. Jornada | 15.09.2021 | Blooming | - | Bolívar | 2:2 | |
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| 19. Jornada | 18.09.2021 | Club Aurora | - | Blooming | 2:0 | ||||
| 20. Jornada | 22.09.2021 | Blooming | - | Real Tomayapo | 0:1 | ||||
| 21. Jornada | 25.09.2021 | Club San José | - | Blooming | 1:2 | |
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| 22. Jornada | 18.10.2021 | Blooming | - | Real Santa Cruz | 3:1 | ||||
| 23. Jornada | 24.10.2021 | Nacional Potosí | - | Blooming | 4:0 | ||||
| 24. Jornada | 28.10.2021 | Blooming | - | Oriente Petrolero | 1:1 | ||||
| 25. Jornada | 30.10.2021 | The Strongest | - | Blooming | 2:1 | ||||
| 26. Jornada | 22.11.2021 | Blooming | - | Jorge Wilstermann | 2:2 | |
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| 27. Jornada | 27.11.2021 | Atlético Palmaflor | - | Blooming | 3:0 | ||||
| 28. Jornada | 01.12.2021 | Blooming | - | Always Ready | 1:2 | |
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| 29. Jornada | 05.12.2021 | Royal Pari | - | Blooming | 4:3 | ||||
| 30. Jornada | 12.12.2021 | Blooming | - | Real Potosí | 1:0 |
Bolivia