| 1. Jornada | 19.02.2022 | LDU Quito | - | Gualaceo SC | 1:0 | ||||
| 4. Jornada | 14.03.2022 | Gualaceo SC | - | Emelec | 2:1 | ||||
| 5. Jornada | 20.03.2022 | 9 de Octubre | - | Gualaceo SC | 1:1 |  |
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| 7. Jornada | 09.04.2022 | Técnico Universitario | - | Gualaceo SC | 1:1 | ||||
| 8. Jornada | 16.04.2022 | Gualaceo SC | - | Mushuc Runa | 3:2 |  |
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| 9. Jornada | 21.04.2022 | Barcelona | - | Gualaceo SC | 0:1 | ||||
| 10. Jornada | 23.04.2022 | Gualaceo SC | - | Orense SC | 2:1 | ||||
| 11. Jornada | 30.04.2022 | Gualaceo SC | - | Macará | 2:1 | |
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| 12. Jornada | 08.05.2022 | Universidad Catolica | - | Gualaceo SC | 3:1 | ||||
| 13. Jornada | 17.05.2022 | Gualaceo SC | - | Guayaquil City | 2:1 | |
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| 14. Jornada | 21.05.2022 | Delfín SC | - | Gualaceo SC | 1:0 | ||||
| 15. Jornada | 28.05.2022 | Gualaceo SC | - | Aucas | 1:4 |
Ecuador