| 1. Jornada | 10.01.2016 | Club León | - | Santos Laguna | 2:0 | ||||
| 2. Jornada | 16.01.2016 | CD Veracruz | - | Club León | 1:3 |  |
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| 3. Jornada | 24.01.2016 | Club León | - | Cruz Azul | 3:2 | |
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| 4. Jornada | 31.01.2016 | UANL Tigres | - | Club León | 3:1 | ||||
| 5. Jornada | 07.02.2016 | Club León | - | Monarcas Morelia | 1:2 | ||||
| 6. Jornada | 14.02.2016 | Deportivo Guadalajara | - | Club León | 0:1 | ||||
| 7. Jornada | 21.02.2016 | Club León | - | Deportivo Toluca | 5:1 | ||||
| 8. Jornada | 28.02.2016 | Club León | - | Chiapas FC | 1:3 | ||||
| 9. Jornada | 05.03.2016 | Club Tijuana | - | Club León | 0:0 | ||||
| 10. Jornada | 13.03.2016 | Club León | - | Gallos Blancos | 2:0 | ||||
| 11. Jornada | 20.03.2016 | CF América | - | Club León | 2:1 | ||||
| 12. Jornada | 03.04.2016 | Club León | - | CF Monterrey | 1:2 | |
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| 13. Jornada | 11.04.2016 | Pumas UNAM | - | Club León | 1:2 | ||||
| 14. Jornada | 17.04.2016 | Club León | - | Puebla FC | 4:1 | ||||
| 15. Jornada | 24.04.2016 | Atlas Guadalajara | - | Club León | 1:1 | ||||
| 16. Jornada | 01.05.2016 | Club León | - | CF Pachuca | 0:0 | ||||
| 17. Jornada | 08.05.2016 | Dorados de Sinaloa | - | Club León | 0:1 |
México