| 1. Jornada | 12.09.2021 | AEK Athen | - | Ionikos Nikea | 3:0 | ||||
| 2. Jornada | 19.09.2021 | OFI Heraklion | - | AEK Athen | 3:3 | ||||
| 3. Jornada | 22.09.2021 | AEK Athen | - | Lamia | 1:0 | ||||
| 4. Jornada | 26.09.2021 | PAOK Saloniki | - | AEK Athen | 2:0 | ||||
| 5. Jornada | 03.10.2021 | Panetolikos | - | AEK Athen | 1:3 | ||||
| 7. Jornada | 24.10.2021 | Volos NFC | - | AEK Athen | 1:3 |  |
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| 9. Jornada | 06.11.2021 | Apollon Smyrnis | - | AEK Athen | 2:2 | ||||
| 10. Jornada | 21.11.2021 | AEK Athen | - | Olympiacos | 2:3 | ||||
| 12. Jornada | 05.12.2021 | AEK Athen | - | Panathinaikos | 1:0 | ||||
| 14. Jornada | 16.12.2021 | Ionikos Nikea | - | AEK Athen | 0:1 | ||||
| 15. Jornada | 20.12.2021 | AEK Athen | - | OFI Heraklion | 1:2 | ||||
| 16. Jornada | 05.01.2022 | Lamia | - | AEK Athen | 0:2 | ||||
| 20. Jornada | 30.01.2022 | AEK Athen | - | Volos NFC | 1:2 | ||||
| 21. Jornada | 02.02.2022 | Aris Saloniki | - | AEK Athen | 2:1 |  |
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| 22. Jornada | 06.02.2022 | AEK Athen | - | Apollon Smyrnis | 3:0 | ||||
| 23. Jornada | 13.02.2022 | Olympiacos | - | AEK Athen | 1:0 | ||||
| 24. Jornada | 20.02.2022 | AEK Athen | - | PAS Giannina | 2:0 | |
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| 25. Jornada | 27.02.2022 | Panathinaikos | - | AEK Athen | 3:0 | ||||
| 26. Jornada | 06.03.2022 | AEK Athen | - | Asteras Tripolis | 2:1 |
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