| 1. Jornada | 03.07.2023 | Santos Laguna | - | Gallos Blancos | 0:2 | ||||
| 2. Jornada | 08.07.2023 | Puebla FC | - | Santos Laguna | 2:3 | ||||
| 3. Jornada | 14.07.2023 | Santos Laguna | - | Atlas Guadalajara | 0:0 | ||||
| 4. Jornada | 21.08.2023 | Cruz Azul | - | Santos Laguna | 2:2 | ||||
| 6. Jornada | 27.08.2023 | Santos Laguna | - | Deportivo Guadalajara | 2:1 | ||||
| 5. Jornada | 31.08.2023 | UANL Tigres | - | Santos Laguna | 3:2 |  |
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| 7. Jornada | 03.09.2023 | Santos Laguna | - | Pumas UNAM | 2:1 |  |
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| 8. Jornada | 19.09.2023 | CF Pachuca | - | Santos Laguna | 3:2 | ||||
| 9. Jornada | 25.09.2023 | Santos Laguna | - | Club Necaxa | 2:5 | ||||
| 11. Jornada | 05.10.2023 | Santos Laguna | - | Club Tijuana | 2:1 | ||||
| 12. Jornada | 09.10.2023 | Santos Laguna | - | Club León | 0:2 | ||||
| 13. Jornada | 22.10.2023 | CF América | - | Santos Laguna | 4:3 | |
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| 14. Jornada | 30.10.2023 | Santos Laguna | - | FC Juárez | 5:1 | ||||
| 15. Jornada | 02.11.2023 | Mazatlán FC | - | Santos Laguna | 3:1 | ||||
| 16. Jornada | 06.11.2023 | Santos Laguna | - | Deportivo Toluca | 3:1 | ||||
| 10. Jornada | 09.11.2023 | CF Monterrey | - | Santos Laguna | 3:0 | ||||
| 17. Jornada | 12.11.2023 | Atlético San Luis | - | Santos Laguna | 0:2 |
Colombia