| 2. Jornada | 15.03.2021 | Blooming | - | Independiente Petrolero | 2:2 | ||||
| 1. Jornada | 20.03.2021 | Independiente Petrolero | - | Oriente Petrolero | 1:0 | ||||
| 5. Jornada | 26.04.2021 | Independiente Petrolero | - | Jorge Wilstermann | 5:4 | ||||
| 6. Jornada | 01.05.2021 | Club Aurora | - | Independiente Petrolero | 3:0 |  |
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| 12. Jornada | 31.07.2021 | Real Santa Cruz | - | Independiente Petrolero | 2:0 | ||||
| 13. Jornada | 04.08.2021 | Independiente Petrolero | - | Real Potosí | 2:1 | |
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| 23. Jornada | 24.10.2021 | Independiente Petrolero | - | Real Tomayapo | 1:0 | ||||
| 25. Jornada | 01.11.2021 | Independiente Petrolero | - | Club San José | 4:0 | ||||
| 26. Jornada | 21.11.2021 | Royal Pari | - | Independiente Petrolero | 3:1 | |
Bolivia