| 3. Jornada | 12.08.2022 | Boston River | - | River Plate | 1:2 | ||||
| 6. Jornada | 21.08.2022 | Defensor Sporting | - | Boston River | 0:1 | ||||
| 5. Jornada | 27.08.2022 | Boston River | - | Fénix | 1:1 | ||||
| 9. Jornada | 19.09.2022 | Boston River | - | Danubio | 0:1 | ||||
| 10. Jornada | 24.09.2022 | Deportivo Maldonado | - | Boston River | 2:1 | ||||
| 11. Jornada | 02.10.2022 | Boston River | - | Rentistas | 3:0 | ||||
| 12. Jornada | 09.10.2022 | Liverpool | - | Boston River | 3:2 | ||||
| 14. Jornada | 17.10.2022 | Montevideo City Torque | - | Boston River | 0:2 | ||||
| 15. Jornada | 24.10.2022 | Boston River | - | Montevideo Wanderers | 2:2 |
Uruguay