| 3. Jornada | 07.08.2021 | Club León [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 1:7 | ||||
| 7. Jornada | 04.09.2021 | Mazatlán FC [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 1:7 | ||||
| 15. Jornada | 30.10.2021 | CF Monterrey [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 1:7 | ||||
| 16. Jornada | 06.11.2021 | Deportivo Guadalajara [Sub 16] | - | Atlas Guadalajara [Sub 16] | 3:0 | ||||
| 17. Jornada | 13.11.2021 | Santos Laguna [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 0:1 | ||||
| 18. Jornada | 20.11.2021 | UANL Tigres [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 2:2 |
México