| 7. Jornada | 18.02.2021 | Atlético San Luis [Sub 20] | - | Santos Laguna [Sub 20] | 0:4 | ||||
| 9. Jornada | 04.03.2021 | Pumas UNAM [Sub 20] | - | Santos Laguna [Sub 20] | 0:0 | ||||
| 11. Jornada | 14.03.2021 | Club Tijuana [Sub 20] | - | Santos Laguna [Sub 20] | 3:1 | ||||
| 14. Jornada | 11.04.2021 | Gallos Blancos [Sub 20] | - | Santos Laguna [Sub 20] | 1:0 |
México