| 6. Jornada | 10.09.2021 | Jong PSV | - | Jong Ajax | 3:1 | ||||
| 5. Jornada | 13.09.2021 | FC Utrecht (J) | - | Jong PSV | 2:1 | ||||
| 7. Jornada | 20.09.2021 | Jong PSV | - | ADO Den Haag | 0:1 | ||||
| 8. Jornada | 24.09.2021 | SBV Excelsior | - | Jong PSV | 3:0 | ||||
| 9. Jornada | 01.10.2021 | Jong PSV | - | VVV-Venlo | 2:1 | ||||
| 11. Jornada | 15.10.2021 | Roda JC Kerkrade | - | Jong PSV | 2:2 | ||||
| 10. Jornada | 18.10.2021 | Jong PSV | - | Telstar | 2:3 | ||||
| 12. Jornada | 22.10.2021 | Almere City FC | - | Jong PSV | 3:5 |  |
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| 13. Jornada | 01.11.2021 | Jong PSV | - | AZ Alkmaar (J) | 2:0 | ||||
| 14. Jornada | 05.11.2021 | Jong PSV | - | TOP Oss | 2:2 | ||||
| 16. Jornada | 19.11.2021 | FC Emmen | - | Jong PSV | 2:0 | ||||
| 15. Jornada | 22.11.2021 | Jong PSV | - | NAC Breda | 0:0 | ||||
| 17. Jornada | 26.11.2021 | MVV | - | Jong PSV | 1:2 | ||||
| 18. Jornada | 06.12.2021 | Jong PSV | - | De Graafschap | 2:3 | ||||
| 19. Jornada | 10.12.2021 | FC Volendam | - | Jong PSV | 3:2 | ||||
| 20. Jornada | 17.12.2021 | Telstar | - | Jong PSV | 0:0 | ||||
| 22. Jornada | 14.01.2022 | VVV-Venlo | - | Jong PSV | 1:4 |
Bélgica
R.D. Congo