| 2. Jornada | 25.07.2021 | Guaireña FC | - | River Plate | 1:2 | ||||
| 3. Jornada | 31.07.2021 | River Plate | - | Cerro Porteño | 0:0 | ||||
| 4. Jornada | 09.08.2021 | Sol de América | - | River Plate | 1:0 | ||||
| 6. Jornada | 22.08.2021 | 12 de Octubre de Itauguá | - | River Plate | 2:2 | ||||
| 7. Jornada | 30.08.2021 | River Plate | - | Guaraní | 1:5 | ||||
| 8. Jornada | 12.09.2021 | Sportivo Luqueño | - | River Plate | 0:2 | ||||
| 9. Jornada | 18.09.2021 | River Plate | - | Libertad | 0:1 | ||||
| 11. Jornada | 03.10.2021 | River Plate | - | Guaireña FC | 1:1 | ||||
| 14. Jornada | 30.10.2021 | Club Nacional | - | River Plate | 1:1 |
Uruguay