| 15. Jornada | 15.08.2021 | Puerto Montt | - | Deportes Iquique | 0:0 | ||||
| 16. Jornada | 24.08.2021 | Coquimbo Unido | - | Deportes Iquique | 3:1 | ||||
| 17. Jornada | 29.08.2021 | Deportes Iquique | - | Fernández Vial | 1:3 | ||||
| 18. Jornada | 02.09.2021 | San Marcos | - | Deportes Iquique | 4:2 | ||||
| 19. Jornada | 05.09.2021 | Deportes Iquique | - | Barnechea | 4:2 |  |
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| 20. Jornada | 16.09.2021 | San Luis | - | Deportes Iquique | 1:1 | ||||
| 21. Jornada | 23.09.2021 | Deportes Iquique | - | Deportes Copiapó | 2:1 | |
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| 24. Jornada | 08.10.2021 | Universidad de Concepción | - | Deportes Iquique | 3:1 | ||||
| 30. Jornada | 13.11.2021 | Deportes Iquique | - | Puerto Montt | 4:2 |  |
Uruguay