| 1. Jornada | 17.02.2022 | Deportes Melipilla | - | Universidad de Concepción | 0:2 |  |
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| 2. Jornada | 24.02.2022 | Rangers | - | Deportes Melipilla | 1:0 | |
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| 3. Jornada | 02.03.2022 | Deportes Melipilla | - | Puerto Montt | 1:1 | ||||
| 4. Jornada | 12.03.2022 | Recoleta | - | Deportes Melipilla | 1:2 | ||||
| 5. Jornada | 16.03.2022 | Deportes Melipilla | - | Deportes Copiapó | 2:1 | ||||
| 8. Jornada | 09.04.2022 | Deportes Melipilla | - | Cobreloa | 0:0 | ||||
| 9. Jornada | 18.04.2022 | San Luis | - | Deportes Melipilla | 2:1 | ||||
| 12. Jornada | 30.04.2022 | Deportes Melipilla | - | Barnechea | 2:1 | ||||
| 13. Jornada | 08.05.2022 | Fernández Vial | - | Deportes Melipilla | 1:1 | ||||
| 16. Jornada | 22.05.2022 | Deportes Melipilla | - | Santa Cruz | 1:0 | ||||
| 22. Jornada | 02.08.2022 | Deportes Copiapó | - | Deportes Melipilla | 2:1 | ||||
| 23. Jornada | 10.08.2022 | Deportes Melipilla | - | Unión San Felipe | 1:0 |
Uruguay