| 1. Jornada | 05.02.2022 | Tauro FC | - | Sporting San Miguelito | 3:3 | ||||
| 2. Jornada | 13.02.2022 | Sporting San Miguelito | - | Plaza Amador | 1:1 | ||||
| 3. Jornada | 20.02.2022 | Árabe Unido | - | Sporting San Miguelito | 0:0 |  |
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| 5. Jornada | 05.03.2022 | Sporting San Miguelito | - | Potros del Este | 1:1 | ||||
| 11. Jornada | 09.04.2022 | Sporting San Miguelito | - | Independiente de La Chorrera | 2:1 | ||||
| 15. Jornada | 30.04.2022 | Sporting San Miguelito | - | Alianza | 1:0 | |
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| 12. Jornada | 04.05.2022 | Sporting San Miguelito | - | Tauro FC | 0:1 |
Panamá