| 2. Jornada | 08.08.2021 | Jocoro FC | - | Once Municipal | 3:4 | ||||
| 3. Jornada | 11.08.2021 | Once Municipal | - | Municipal Limeño | 4:1 |  |
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| 4. Jornada | 15.08.2021 | Platense Zacatecoluca | - | Once Municipal | 1:1 | ||||
| 7. Jornada | 29.08.2021 | AD Chalatenango | - | Once Municipal | 1:2 | ||||
| 5. Jornada | 10.09.2021 | Alianza | - | Once Municipal | 1:0 |  |
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| 8. Jornada | 12.09.2021 | Once Municipal | - | FAS | 1:3 | ||||
| 10. Jornada | 19.09.2021 | Once Municipal | - | Atlético Marte | 0:0 | ||||
| 15. Jornada | 24.10.2021 | Once Municipal | - | Platense Zacatecoluca | 1:1 | ||||
| 19. Jornada | 14.11.2021 | FAS | - | Once Municipal | 3:2 | ||||
| 21. Jornada | 21.11.2021 | Atlético Marte | - | Once Municipal | 1:4 | |
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| 22. Jornada | 27.11.2021 | Once Municipal | - | Santa Tecla FC | 4:3 |
El Salvador
Estados Unidos