| 3. Jornada | 07.08.2021 | MFK Zemplín Michalovce | - | AS Trenčín | 1:2 | ||||
| 4. Jornada | 13.08.2021 | AS Trenčín | - | MFK Ružomberok | 1:1 | ||||
| 6. Jornada | 28.08.2021 | AS Trenčín | - | ŠKF Sereď | 0:0 | ||||
| 7. Jornada | 11.09.2021 | MŠK Žilina | - | AS Trenčín | 1:3 | ||||
| 8. Jornada | 18.09.2021 | AS Trenčín | - | FK Senica | 3:3 |  |
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| 9. Jornada | 24.09.2021 | FK Pohronie | - | AS Trenčín | 2:2 | |
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| 10. Jornada | 03.10.2021 | AS Trenčín | - | Spartak Trnava | 0:1 | ||||
| 11. Jornada | 15.10.2021 | Tatran Liptovský Mikuláš | - | AS Trenčín | 2:1 | ||||
| 12. Jornada | 23.10.2021 | Zlaté Moravce | - | AS Trenčín | 0:1 | ||||
| 13. Jornada | 31.10.2021 | AS Trenčín | - | Slovan Bratislava | 2:3 | ||||
| 15. Jornada | 19.11.2021 | MFK Ružomberok | - | AS Trenčín | 3:0 | ||||
| 16. Jornada | 27.11.2021 | AS Trenčín | - | FC DAC 1904 | 0:1 | ||||
| 18. Jornada | 11.12.2021 | AS Trenčín | - | MŠK Žilina | 1:3 | ||||
| 19. Jornada | 18.12.2021 | FK Senica | - | AS Trenčín | 1:0 | ||||
| 20. Jornada | 12.02.2022 | AS Trenčín | - | FK Pohronie | 3:0 |
Eslovaquia