| 21. Jornada | 20.02.2021 | FC Milsami | - | Speranţa Nisporeni | 3:0 | ||||
| 22. Jornada | 24.02.2021 | Speranţa Nisporeni | - | Dinamo-Auto | 0:4 | ||||
| 24. Jornada | 07.03.2021 | Speranţa Nisporeni | - | CS Petrocub | 1:3 | ||||
| 25. Jornada | 14.03.2021 | Dacia Buiucani | - | Speranţa Nisporeni | 4:1 |  |
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| 27. Jornada | 11.04.2021 | Speranţa Nisporeni | - | FC Sfîntul Gheorghe | 0:3 | ||||
| 29. Jornada | 23.04.2021 | FC Zimbru | - | Speranţa Nisporeni | 6:0 | ||||
| 26. Jornada | 26.04.2021 | FC Codru Lozova | - | Speranţa Nisporeni | 1:2 | ||||
| 30. Jornada | 30.04.2021 | Speranţa Nisporeni | - | FC Milsami | 0:4 | ||||
| 31. Jornada | 07.05.2021 | Dinamo-Auto | - | Speranţa Nisporeni | 0:0 | ||||
| 32. Jornada | 11.05.2021 | Speranţa Nisporeni | - | FC Floreşti | 1:3 |
Moldavia