| 4. Jornada | 12.03.2022 | Recoleta | - | Deportes Melipilla | 1:2 | ||||
| 5. Jornada | 16.03.2022 | Deportes Melipilla | - | Deportes Copiapó | 2:1 |  |
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| 6. Jornada | 24.03.2022 | Unión San Felipe | - | Deportes Melipilla | 1:0 | ||||
| 8. Jornada | 09.04.2022 | Deportes Melipilla | - | Cobreloa | 0:0 | ||||
| 9. Jornada | 18.04.2022 | San Luis | - | Deportes Melipilla | 2:1 | ||||
| 11. Jornada | 26.04.2022 | Deportes Temuco | - | Deportes Melipilla | 1:1 | ||||
| 15. Jornada | 16.05.2022 | Santiago Morning | - | Deportes Melipilla | 1:1 | ||||
| 16. Jornada | 22.05.2022 | Deportes Melipilla | - | Santa Cruz | 1:0 | ||||
| 17. Jornada | 29.05.2022 | Deportes Iquique | - | Deportes Melipilla | 3:0 | ||||
| 20. Jornada | 19.07.2022 | Puerto Montt | - | Deportes Melipilla | 2:0 | ||||
| 23. Jornada | 10.08.2022 | Deportes Melipilla | - | Unión San Felipe | 1:0 | ||||
| 25. Jornada | 25.08.2022 | Cobreloa | - | Deportes Melipilla | 1:0 | ||||
| 31. Jornada | 09.10.2022 | CD Magallanes | - | Deportes Melipilla | 7:0 | ||||
| 32. Jornada | 18.10.2022 | Deportes Melipilla | - | Santiago Morning | 2:1 | ||||
| 33. Jornada | 24.10.2022 | Santa Cruz | - | Deportes Melipilla | 2:1 |
Argentina