| 4. Jornada | 21.08.2021 | Juventus Managua | - | Real Estelí FC | 1:3 |  |
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| 5. Jornada | 30.08.2021 | Real Estelí FC | - | ART Municipal Jalapa | 2:0 | ||||
| 6. Jornada | 02.09.2021 | Real Estelí FC | - | UNAN Managua | 4:1 | |
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| 7. Jornada | 13.09.2021 | Diriangén FC | - | Real Estelí FC | 3:2 |  |
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| 10. Jornada | 02.10.2021 | H&H Export Sébaco | - | Real Estelí FC | 1:3 | ||||
| 8. Jornada | 07.10.2021 | Real Estelí FC | - | CD Walter Ferretti | 1:1 | ||||
| 11. Jornada | 11.10.2021 | Real Madriz | - | Real Estelí FC | 1:2 | |
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| 12. Jornada | 17.10.2021 | Real Estelí FC | - | Managua FC | 1:0 | ||||
| 13. Jornada | 21.10.2021 | Real Estelí FC | - | Juventus Managua | 3:0 | ||||
| 14. Jornada | 24.10.2021 | ART Municipal Jalapa | - | Real Estelí FC | 2:1 | ||||
| 15. Jornada | 31.10.2021 | Real Estelí FC | - | Diriangén FC | 3:0 | |
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| 17. Jornada | 19.11.2021 | CD Walter Ferretti | - | Real Estelí FC | 4:0 | |
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Brasil