| 5. Jornada | 30.08.2021 | Real Estelí FC | - | ART Municipal Jalapa | 2:0 |  |
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| 6. Jornada | 03.09.2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 | ||||
| 8. Jornada | 20.09.2021 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | ||||
| 9. Jornada | 27.09.2021 | ART Municipal Jalapa | - | Diriangén FC | 2:1 | ||||
| 11. Jornada | 10.10.2021 | Managua FC | - | ART Municipal Jalapa | 3:0 | ||||
| 18. Jornada | 22.11.2021 | Diriangén FC | - | ART Municipal Jalapa | 5:0 |
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