| 1. Jornada | 04.02.2018 | Defensor Sporting | - | Atenas | 3:0 | ||||
| 2. Jornada | 11.02.2018 | Danubio | - | Defensor Sporting | 2:1 | ||||
| 3. Jornada | 18.02.2018 | Defensor Sporting | - | Torque | 2:1 | ||||
| 4. Jornada | 24.02.2018 | Rampla Juniors | - | Defensor Sporting | 1:1 | ||||
| 5. Jornada | 04.03.2018 | Defensor Sporting | - | Fénix | 3:2 | ||||
| 6. Jornada | 10.03.2018 | Nacional | - | Defensor Sporting | 2:0 | ||||
| 7. Jornada | 17.03.2018 | Defensor Sporting | - | Progreso | 1:1 | ||||
| 8. Jornada | 24.03.2018 | Defensor Sporting | - | CA Cerro | 2:1 | ||||
| 9. Jornada | 28.03.2018 | Racing | - | Defensor Sporting | 2:2 | ||||
| 10. Jornada | 01.04.2018 | Defensor Sporting | - | River Plate | 5:2 |  |
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| 11. Jornada | 08.04.2018 | Montevideo Wanderers | - | Defensor Sporting | 1:2 | ||||
| 12. Jornada | 14.04.2018 | Defensor Sporting | - | Liverpool | 1:0 |  |
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| 14. Jornada | 01.05.2018 | Defensor Sporting | - | Boston River | 2:1 | ||||
| 15. Jornada | 05.05.2018 | Peñarol | - | Defensor Sporting | 4:1 |
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