| 2. Jornada | 18.09.2021 | Villa Española | - | Sud América | 1:2 | ||||
| 3. Jornada | 25.09.2021 | Plaza Colonia | - | Villa Española | 4:0 | ||||
| 4. Jornada | 02.10.2021 | Villa Española | - | Fénix | 1:2 | ||||
| 5. Jornada | 10.10.2021 | Boston River | - | Villa Española | 1:0 | ||||
| 6. Jornada | 17.10.2021 | Villa Española | - | Montevideo Wanderers | 2:2 |  |
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| 7. Jornada | 20.10.2021 | Rentistas | - | Villa Española | 3:1 | ||||
| 8. Jornada | 24.10.2021 | Villa Española | - | Peñarol | 1:3 |  |
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| 14. Jornada | 30.11.2021 | River Plate | - | Villa Española | 4:2 |
Uruguay