| 1. Jornada | 06.02.2022 | Boston River | - | Plaza Colonia | 0:0 |  |
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| 2. Jornada | 12.02.2022 | Plaza Colonia | - | River Plate | 0:1 | ||||
| 6. Jornada | 20.03.2022 | Plaza Colonia | - | Albion | 1:1 | ||||
| 7. Jornada | 02.04.2022 | Nacional | - | Plaza Colonia | 1:0 | |
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| 8. Jornada | 09.04.2022 | Plaza Colonia | - | Danubio | 1:1 | ||||
| 10. Jornada | 25.04.2022 | Plaza Colonia | - | Rentistas | 0:3 | |
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| 11. Jornada | 07.05.2022 | Liverpool | - | Plaza Colonia | 1:0 | |
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| 12. Jornada | 14.05.2022 | Plaza Colonia | - | Peñarol | 0:1 | |
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| 14. Jornada | 29.05.2022 | Plaza Colonia | - | Montevideo Wanderers | 1:0 | |
Uruguay