| 4. Jornada | 25.06.2021 | Uruguay Montevideo | - | Albion | 2:2 |  |
 |
||
| 6. Jornada | 08.07.2021 | Danubio | - | Uruguay Montevideo | 1:0 | ||||
| 7. Jornada | 14.07.2021 | Uruguay Montevideo | - | Rocha | 2:1 | ||||
| 8. Jornada | 21.07.2021 | CA Cerro | - | Uruguay Montevideo | 0:1 | ||||
| 10. Jornada | 05.08.2021 | Central Español | - | Uruguay Montevideo | 1:3 | ||||
| 11. Jornada | 12.08.2021 | Uruguay Montevideo | - | Atenas | 0:0 | ||||
| 12. Jornada | 16.09.2021 | Uruguay Montevideo | - | Racing | 1:2 | ||||
| 16. Jornada | 13.10.2021 | Rampla Juniors | - | Uruguay Montevideo | 1:1 | ||||
| 17. Jornada | 19.10.2021 | Uruguay Montevideo | - | Danubio | 2:3 |  |
|||
| 18. Jornada | 27.10.2021 | Rocha | - | Uruguay Montevideo | 1:2 | |
|||
| 19. Jornada | 03.11.2021 | Uruguay Montevideo | - | CA Cerro | 1:2 | ||||
| 20. Jornada | 10.11.2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 | ||||
| 21. Jornada | 18.11.2021 | Uruguay Montevideo | - | Central Español | 0:3 | ||||
| 22. Jornada | 23.11.2021 | Atenas | - | Uruguay Montevideo | 0:0 |
Uruguay