| 1. Jornada | 18.01.2021 | Boston River | - | Deportivo Maldonado | 5:0 |  |
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| 2. Jornada | 22.01.2021 | Rentistas | - | Boston River | 0:1 |  |
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| 4. Jornada | 04.02.2021 | Montevideo Wanderers | - | Boston River | 2:2 | ||||
| 6. Jornada | 11.02.2021 | River Plate | - | Boston River | 3:1 | |
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| 12. Jornada | 12.03.2021 | Defensor Sporting | - | Boston River | 1:2 | |
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| 13. Jornada | 19.03.2021 | Boston River | - | Danubio | 1:5 | ||||
| 15. Jornada | 29.03.2021 | Boston River | - | Liverpool | 1:0 |
Uruguay