| 5. Jornada | 07.02.2021 | CA Cerro | - | Progreso | 2:0 | ||||
| 6. Jornada | 11.02.2021 | Progreso | - | Defensor Sporting | 3:3 |  |
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| 8. Jornada | 18.02.2021 | Progreso | - | Nacional | 0:1 | ||||
| 9. Jornada | 23.02.2021 | Boston River | - | Progreso | 2:3 | ||||
| 10. Jornada | 02.03.2021 | Progreso | - | Deportivo Maldonado | 1:1 | ||||
| 11. Jornada | 08.03.2021 | Rentistas | - | Progreso | 1:3 | |
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| 12. Jornada | 14.03.2021 | Cerro Largo | - | Progreso | 1:0 | ||||
| 13. Jornada | 21.03.2021 | Montevideo Wanderers | - | Progreso | 3:0 |
Uruguay