| 2. Jornada | 18.09.2021 | PAS Giannina | - | Panathinaikos | 1:0 | ||||
| 3. Jornada | 22.09.2021 | Aris Saloniki | - | Panathinaikos | 1:0 | ||||
| 4. Jornada | 26.09.2021 | Panathinaikos | - | Volos NFC | 5:1 | ||||
| 5. Jornada | 03.10.2021 | Olympiacos | - | Panathinaikos | 0:0 | ||||
| 9. Jornada | 07.11.2021 | Panathinaikos | - | PAOK Saloniki | 1:3 | ||||
| 10. Jornada | 22.11.2021 | Lamia | - | Panathinaikos | 1:3 |  |
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| 11. Jornada | 28.11.2021 | Panathinaikos | - | Panetolikos | 2:0 | |
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| 12. Jornada | 05.12.2021 | AEK Athen | - | Panathinaikos | 1:0 | ||||
| 13. Jornada | 11.12.2021 | Panathinaikos | - | Atromitos | 2:0 | ||||
| 15. Jornada | 19.12.2021 | Panathinaikos | - | PAS Giannina | 2:0 | ||||
| 16. Jornada | 05.01.2022 | Panathinaikos | - | Aris Saloniki | 2:0 | ||||
| 17. Jornada | 09.01.2022 | Volos NFC | - | Panathinaikos | 3:1 | ||||
| 18. Jornada | 16.01.2022 | Panathinaikos | - | Olympiacos | 0:0 |
Italia