| 1. Jornada | 22.07.2018 | Danubio | - | Progreso | 2:2 |  |
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| 2. Jornada | 28.07.2018 | Defensor Sporting | - | Danubio | 1:2 | ||||
| 3. Jornada | 04.08.2018 | Danubio | - | Racing | 1:1 |  |
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| 4. Jornada | 12.08.2018 | River Plate | - | Danubio | 1:2 | ||||
| 5. Jornada | 18.08.2018 | Danubio | - | Montevideo Wanderers | 2:2 | |
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| 6. Jornada | 26.08.2018 | Liverpool | - | Danubio | 3:0 | ||||
| 8. Jornada | 09.09.2018 | Boston River | - | Danubio | 0:0 | ||||
| 9. Jornada | 16.09.2018 | Danubio | - | Peñarol | 0:2 | ||||
| 11. Jornada | 07.10.2018 | Danubio | - | CA Cerro | 0:0 | ||||
| 12. Jornada | 14.10.2018 | Danubio | - | Torque | 3:1 | |
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| 13. Jornada | 21.10.2018 | Rampla Juniors | - | Danubio | 0:0 | ||||
| 14. Jornada | 28.10.2018 | Danubio | - | Fénix | 1:1 | |
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| 15. Jornada | 04.11.2018 | Nacional | - | Danubio | 1:0 |
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