| 4. Jornada | 29.01.2012 | Club Tijuana | - | Santos Laguna | 1:3 | ||||
| 5. Jornada | 05.02.2012 | Santos Laguna | - | Pumas UNAM | 2:1 | ||||
| 7. Jornada | 19.02.2012 | Santos Laguna | - | CF Monterrey | 1:1 | ||||
| 8. Jornada | 26.02.2012 | Deportivo Guadalajara | - | Santos Laguna | 2:1 |  |
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| 9. Jornada | 04.03.2012 | Santos Laguna | - | Club San Luis | 5:2 | ||||
| 10. Jornada | 11.03.2012 | Santos Laguna | - | Puebla FC | 3:1 | ||||
| 12. Jornada | 25.03.2012 | Santos Laguna | - | Gallos Blancos (old) | 2:0 | |
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| 13. Jornada | 01.04.2012 | Deportivo Toluca | - | Santos Laguna | 1:3 | ||||
| 14. Jornada | 08.04.2012 | Santos Laguna | - | Estudiantes Tecos | 1:1 | |
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| 16. Jornada | 22.04.2012 | Santos Laguna | - | UANL Tigres | 3:0 | ||||
| 17. Jornada | 29.04.2012 | Atlas Guadalajara | - | Santos Laguna | 1:3 |
Panamá
México 