| 3. Jornada | 17.04.2022 | Unión Huaral | - | Santos FC | 0:0 | ||||
| 4. Jornada | 24.04.2022 | Santos FC | - | Juan Aurich | 4:0 |  |
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| 5. Jornada | 01.05.2022 | Alianza Universidad | - | Santos FC | 4:1 | ||||
| 6. Jornada | 08.05.2022 | Santos FC | - | Comerciantes Unidos | 2:0 | ||||
| 7. Jornada | 15.05.2022 | Unión Comercio | - | Santos FC | 3:1 | |
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| 8. Jornada | 22.05.2022 | Santos FC | - | Cusco FC | 1:2 | ||||
| 9. Jornada | 29.05.2022 | Alfonso Ugarte | - | Santos FC | 1:1 | ||||
| 10. Jornada | 05.06.2022 | Santos FC | - | Chavelines Juniors | 3:0 |  |
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| 11. Jornada | 11.06.2022 | Pirata | - | Santos FC | 0:1 | ||||
| 12. Jornada | 19.06.2022 | Santos FC | - | Llacuabamba | 2:2 | |
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Colombia