| 2. Jornada | 09.07.2022 | Deportivo Coopsol | - | Santos FC | 0:1 | ||||
| 3. Jornada | 17.07.2022 | Santos FC | - | Unión Huaral | 1:0 |  |
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| 4. Jornada | 23.07.2022 | Juan Aurich | - | Santos FC | 0:1 | ||||
| 5. Jornada | 31.07.2022 | Santos FC | - | Alianza Universidad | 2:2 |  |
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| 7. Jornada | 14.08.2022 | Santos FC | - | Unión Comercio | 1:0 | ||||
| 8. Jornada | 21.08.2022 | Cusco FC | - | Santos FC | 4:1 | ||||
| 9. Jornada | 28.08.2022 | Santos FC | - | Alfonso Ugarte | 1:0 | ||||
| 10. Jornada | 04.09.2022 | Chavelines Juniors | - | Santos FC | 1:2 | ||||
| 11. Jornada | 11.09.2022 | Santos FC | - | Pirata | 1:2 | ||||
| 12. Jornada | 18.09.2022 | Llacuabamba | - | Santos FC | 3:0 | ||||
| 13. Jornada | 25.09.2022 | Santos FC | - | Los Chankas | 5:0 | |
Colombia