| 2. Jornada | 31.07.2022 | Plaza Amador | - | Sporting San Miguelito | 1:1 |  |
|||
| 3. Jornada | 08.08.2022 | Sporting San Miguelito | - | Árabe Unido | 0:0 | ||||
| 4. Jornada | 11.08.2022 | Sporting San Miguelito | - | Tauro FC | 3:1 | |
|||
| 5. Jornada | 14.08.2022 | Potros del Este | - | Sporting San Miguelito | 1:3 | ||||
| 7. Jornada | 28.08.2022 | Herrera FC | - | Sporting San Miguelito | 0:0 | ||||
| 8. Jornada | 03.09.2022 | Sporting San Miguelito | - | Veraguas United | 3:2 | ||||
| 9. Jornada | 12.09.2022 | Sporting San Miguelito | - | San Francisco FC | 2:1 | ||||
| 11. Jornada | 24.09.2022 | Independiente de La Chorrera | - | Sporting San Miguelito | 0:2 | |
|||
| 13. Jornada | 02.10.2022 | Sporting San Miguelito | - | Plaza Amador | 1:1 | ||||
| 14. Jornada | 08.10.2022 | Árabe Unido | - | Sporting San Miguelito | 1:1 | |
|||
| 16. Jornada | 22.10.2022 | Sporting San Miguelito | - | Potros del Este | 3:2 |
Colombia