| 5. Jornada | 22.08.2021 | Isidro Metapán | - | Municipal Limeño | 1:0 | ||||
| 12. Jornada | 02.10.2021 | Atlético Marte | - | Isidro Metapán | 2:0 | ||||
| 13. Jornada | 17.10.2021 | Isidro Metapán | - | Santa Tecla FC | 1:1 | ||||
| 14. Jornada | 21.10.2021 | CD Águila | - | Isidro Metapán | 4:0 | ||||
| 15. Jornada | 24.10.2021 | Isidro Metapán | - | Jocoro FC | 1:1 | ||||
| 17. Jornada | 03.11.2021 | Isidro Metapán | - | Platense Zacatecoluca | 1:0 | ||||
| 18. Jornada | 06.11.2021 | Alianza | - | Isidro Metapán | 1:0 | ||||
| 19. Jornada | 14.11.2021 | Isidro Metapán | - | Luis Ángel Firpo | 2:1 | ||||
| 20. Jornada | 18.11.2021 | Once Municipal | - | Isidro Metapán | 1:1 |
El Salvador