| 3. Jornada | 05.09.2010 | River Plate | - | Central Español | 1:3 | ||||
| 4. Jornada | 18.09.2010 | Racing | - | River Plate | 2:0 | ||||
| 5. Jornada | 25.09.2010 | River Plate | - | Tacuarembó | 2:0 | ||||
| 6. Jornada | 03.10.2010 | Danubio | - | River Plate | 1:2 | ||||
| 7. Jornada | 09.10.2010 | River Plate | - | Peñarol | 2:1 | ||||
| 8. Jornada | 16.10.2010 | CA Cerro | - | River Plate | 0:0 | ||||
| 9. Jornada | 24.10.2010 | River Plate | - | Liverpool | 1:2 | ||||
| 14. Jornada | 27.11.2010 | River Plate | - | Fénix | 1:2 | ||||
| 15. Jornada | 05.12.2010 | Bella Vista | - | River Plate | 1:0 |
Uruguay