| 1. Jornada | 20.03.2021 | Club San José | - | Atlético Palmaflor | 1:3 | ||||
| 3. Jornada | 03.04.2021 | Club San José | - | Royal Pari | 0:3 | ||||
| 4. Jornada | 12.04.2021 | Real Potosí | - | Club San José | 3:0 | ||||
| 6. Jornada | 04.05.2021 | Blooming | - | Club San José | 4:0 | ||||
| 7. Jornada | 08.05.2021 | Club San José | - | Bolívar | 0:5 | ||||
| 18. Jornada | 11.09.2021 | Royal Pari | - | Club San José | 6:1 | ||||
| 20. Jornada | 21.09.2021 | CD Guabirá | - | Club San José | 4:0 | ||||
| 21. Jornada | 25.09.2021 | Club San José | - | Blooming | 1:2 | ||||
| 22. Jornada | 20.10.2021 | Bolívar | - | Club San José | 4:1 | ||||
| 23. Jornada | 22.10.2021 | Club San José | - | Club Aurora | 1:4 | ||||
| 24. Jornada | 28.10.2021 | Real Tomayapo | - | Club San José | 1:0 | ||||
| 25. Jornada | 01.11.2021 | Independiente Petrolero | - | Club San José | 4:0 | ||||
| 28. Jornada | 30.11.2021 | Club San José | - | Oriente Petrolero | 0:2 |  |
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| 29. Jornada | 05.12.2021 | The Strongest | - | Club San José | 2:0 |
Bolivia