| 1. Jornada | 24.07.2021 | MFK Ružomberok | - | FK Senica | 0:0 | ||||
| 4. Jornada | 14.08.2021 | FK Senica | - | FC DAC 1904 | 1:1 | ||||
| 5. Jornada | 22.08.2021 | MŠK Žilina | - | FK Senica | 3:0 | ||||
| 8. Jornada | 18.09.2021 | AS Trenčín | - | FK Senica | 3:3 | ||||
| 10. Jornada | 02.10.2021 | ŠKF Sereď | - | FK Senica | 2:1 | ||||
| 12. Jornada | 23.10.2021 | FK Senica | - | MFK Ružomberok | 0:2 | ||||
| 18. Jornada | 11.12.2021 | FK Pohronie | - | FK Senica | 0:1 | ||||
| 19. Jornada | 18.12.2021 | FK Senica | - | AS Trenčín | 1:0 |
Eslovaquia