| 1. Jornada | 23.08.2020 | MFK Karviná | - | Baník Ostrava | 0:0 |  |
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| 2. Jornada | 29.08.2020 | SFC Opava | - | MFK Karviná | 1:2 | ||||
| 3. Jornada | 13.09.2020 | MFK Karviná | - | Sparta Praga | 2:5 | ||||
| 4. Jornada | 20.09.2020 | Slovan Liberec | - | MFK Karviná | 1:1 | ||||
| 5. Jornada | 26.09.2020 | MFK Karviná | - | FK Mladá Boleslav | 0:0 | ||||
| 6. Jornada | 03.10.2020 | Zbrojovka Brno | - | MFK Karviná | 0:2 | ||||
| 7. Jornada | 08.11.2020 | MFK Karviná | - | Bohemians Praha 1905 | 2:1 | |
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| 8. Jornada | 21.11.2020 | Sigma Olomouc | - | MFK Karviná | 3:0 | ||||
| 9. Jornada | 28.11.2020 | MFK Karviná | - | FC Fastav Zlín | 0:2 | ||||
| 15. Jornada | 16.01.2021 | 1. FC Slovácko | - | MFK Karviná | 2:0 | ||||
| 16. Jornada | 23.01.2021 | MFK Karviná | - | Slavia Praga | 1:3 |
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