| 6. Jornada | 12.09.2020 | MFK Zemplín Michalovce | - | AS Trenčín | 1:1 | ||||
| 7. Jornada | 19.09.2020 | MFK Ružomberok | - | MFK Zemplín Michalovce | 4:0 |  |
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| 9. Jornada | 03.10.2020 | ŠKF Sereď | - | MFK Zemplín Michalovce | 1:1 | ||||
| 10. Jornada | 17.10.2020 | MFK Zemplín Michalovce | - | FC DAC 1904 | 2:4 | ||||
| 11. Jornada | 24.10.2020 | FC Nitra | - | MFK Zemplín Michalovce | 1:1 | ||||
| 12. Jornada | 31.10.2020 | Spartak Trnava | - | MFK Zemplín Michalovce | 1:2 | ||||
| 15. Jornada | 28.11.2020 | Zlaté Moravce | - | MFK Zemplín Michalovce | 0:0 | ||||
| 16. Jornada | 05.12.2020 | MFK Zemplín Michalovce | - | MŠK Žilina | 1:1 | |
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| 18. Jornada | 16.12.2020 | MFK Zemplín Michalovce | - | MFK Ružomberok | 4:3 |  |
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| 19. Jornada | 14.02.2021 | FK Pohronie | - | MFK Zemplín Michalovce | 1:1 | ||||
| 20. Jornada | 20.02.2021 | MFK Zemplín Michalovce | - | ŠKF Sereď | 0:2 | ||||
| 21. Jornada | 27.02.2021 | FC DAC 1904 | - | MFK Zemplín Michalovce | 2:1 | ||||
| 22. Jornada | 06.03.2021 | MFK Zemplín Michalovce | - | FC Nitra | 1:0 |
Eslovaquia