| 1. Jornada | 11.02.2022 | Unión de Santa Fe II | - | River Plate II | 0:0 | ||||
| 2. Jornada | 15.02.2022 | River Plate II | - | Patronato de Paraná II | 1:0 | ||||
| 3. Jornada | 19.02.2022 | Newell's Old Boys II | - | River Plate II | 1:2 |  |
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| 4. Jornada | 24.02.2022 | River Plate II | - | Racing Club II | 4:2 | |
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| 5. Jornada | 04.03.2022 | San Lorenzo II | - | River Plate II | 0:4 | |
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| 9. Jornada | 09.04.2022 | River Plate II | - | Argentinos Juniors II | 0:0 |
Colombia