| 1. Jornada | 11.09.2021 | Panathinaikos | - | Apollon Smyrnis | 4:0 | ||||
| 2. Jornada | 19.09.2021 | Apollon Smyrnis | - | Volos NFC | 1:3 | ||||
| 3. Jornada | 22.09.2021 | Olympiacos | - | Apollon Smyrnis | 4:1 | ||||
| 6. Jornada | 16.10.2021 | Apollon Smyrnis | - | Asteras Tripolis | 0:1 | ||||
| 8. Jornada | 30.10.2021 | PAOK Saloniki | - | Apollon Smyrnis | 4:1 | ||||
| 9. Jornada | 06.11.2021 | Apollon Smyrnis | - | AEK Athen | 2:2 | ||||
| 10. Jornada | 21.11.2021 | Panetolikos | - | Apollon Smyrnis | 1:0 |
Rumania