| 2. Jornada | 12.09.2021 | AEK Larnaca | - | Omonia Nikosia | 2:1 |  |
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| 4. Jornada | 26.09.2021 | Omonia Nikosia | - | Paphos FC | 1:1 | ||||
| 5. Jornada | 03.10.2021 | Olympiacos Nikosia | - | Omonia Nikosia | 1:0 | ||||
| 6. Jornada | 17.10.2021 | Omonia Nikosia | - | Apollon Limassol | 1:0 | ||||
| 7. Jornada | 25.10.2021 | PAEEK | - | Omonia Nikosia | 1:0 |  |
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| 8. Jornada | 29.10.2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 | ||||
| 9. Jornada | 07.11.2021 | Ethnikos Achna | - | Omonia Nikosia | 0:2 | |
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| 10. Jornada | 21.11.2021 | Omonia Nikosia | - | Aris Limassol | 3:0 | |
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| 12. Jornada | 05.12.2021 | AEL Limassol | - | Omonia Nikosia | 0:1 | ||||
| 13. Jornada | 13.12.2021 | Omonia Nikosia | - | AEK Larnaca | 1:1 | |
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| 1. Jornada | 22.12.2021 | Omonia Nikosia | - | AEL Limassol | 1:0 | ||||
| 11. Jornada | 26.12.2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 | |
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| 15. Jornada | 05.01.2022 | Paphos FC | - | Omonia Nikosia | 1:1 | ||||
| 16. Jornada | 10.01.2022 | Omonia Nikosia | - | Olympiacos Nikosia | 1:0 | |
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| 19. Jornada | 29.01.2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 | ||||
| 20. Jornada | 07.02.2022 | Omonia Nikosia | - | Ethnikos Achna | 0:2 | |
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| 21. Jornada | 16.02.2022 | Aris Limassol | - | Omonia Nikosia | 0:2 | |
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