| 4. Jornada | 12.03.2022 | Recoleta | - | Deportes Melipilla | 1:2 | ||||
| 5. Jornada | 16.03.2022 | Deportes Melipilla | - | Deportes Copiapó | 2:1 | ||||
| 19. Jornada | 12.07.2022 | Deportes Melipilla | - | Rangers | 1:2 | ||||
| 20. Jornada | 19.07.2022 | Puerto Montt | - | Deportes Melipilla | 2:0 | ||||
| 21. Jornada | 26.07.2022 | Deportes Melipilla | - | Recoleta | 1:2 | ||||
| 22. Jornada | 02.08.2022 | Deportes Copiapó | - | Deportes Melipilla | 2:1 |  |
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| 28. Jornada | 13.09.2022 | Deportes Melipilla | - | Deportes Temuco | 0:1 | ||||
| 29. Jornada | 24.09.2022 | Barnechea | - | Deportes Melipilla | 4:2 | ||||
| 30. Jornada | 03.10.2022 | Deportes Melipilla | - | Fernández Vial | 2:2 | ||||
| 31. Jornada | 09.10.2022 | CD Magallanes | - | Deportes Melipilla | 7:0 |
Chile